Shops, restaurants and schools will be closed across most of Italy on Monday, with PM Mario Draghi warning of a “new wave” of the coronavirus outbreak.
For three days over Easter, 3-5 April, there will be a total shutdown.
Italy, which one year ago imposed one of the first national lockdowns, is once again struggling to contain the rapid spread of infections.
The country has reported more than 100,000 Covid-related deaths, Europe’s second highest tally after the UK.
Italy’s vaccination campaign has been hit by delays, as has been seen elsewhere in the European Union.
Last week the government in Rome blocked the export of 250,000 doses of the Oxford-AstraZeneca vaccine to Australia in a bid to address shortfalls of vaccines.Elsewhere, Bulgaria, Denmark and Norway have all paused the use of the Oxford-AstraZeneca vaccine over fears it causes blood clots.
The World Health Organization said on Friday there was no indication this was true, stressing that countries should not stop using the vaccine.
In other developments across Europe:
Poland registered nearly 19,000 new daily cases on Friday – the highest number since November
Germany reported a rapid rise in infections among schoolchildren, with new Covid variants blamed
In France, the number of patients in intensive care units exceeded 4,000 – the record figure for more than three months. The government has not ruled out more regional lockdowns
Slovakia and the Czech Republic were hit by government crises over buying non-EU approved vaccines